Pain and Inflammation
What Enables The Ingredients In Fibrolief To Be So Effective At Relieving The Pain And Symptoms?
Turmeric has been used medicinally for over 2500 years!
Curcumin is a potent anti-oxidant with insanely powerful anti-inflammatory and pain relieving properties.
This marvel of nature has virtually no side-effects and offers vast benefits to fibromyalgia sufferers.
Unfortunately, curcumin has long been known to have poor bioavailability, meaning the rate at which it is absorbed
is minimal. However, we also include BioPerine(C) in our formula which has been shown to increase the effectiveness
Boswellia AKBA (ApresFlex(C))
Boswellia is a popular herb used for its benefits in fighting inflammation. Its anti-inflammatory effects involve many processes that the body uses to help heal itself, and could correlate to benefiting many chronic illnesses, such as arthritis and fibromyalgia.
It has a long history of use, particularly in India, where it is used in combination with curcumin to relieve arthritis pain. A double-blind, placebo-controlled, cross
over study concluded that the care of osteoarthritis with this herbomineral formulation reduced the painful symptoms (Kulkarni, RR, 1991).
Boswellia Serrata extract providing Acetyl-11-keto-β-boswellic acid (AKBA) has been shown to increase joint mobility and ease stiff joints. We only use Apresflex(C) which offers highly concentrated levels of AKBA not found in most supplements.
White Willow Bark Extract
White Willow Bark extract contains the active ingredient salicin which is a Cox-1 and Cox-2 inhibitor, and acts as an anti-inflammatory and also reduces pain by inhibiting prostaglandins. Animal experimentation at Cairo University compared willow bark extract to ASA (aspirin), and found that willow bark was equally or more effective as aspirin reducing inflammation; even though the salicin content was lower than an equivalent dose of ASA. It is recommended to take white willow bark instead of aspirin because it is less irritating to the stomach lining.
Celery Seed Extract
Celery seed extract has been used as a pain reliever for arthritis, fibromyalgia and gout. It is known to help reduce muscle spasms and to alleviate painful gas and bloating. It is also known to aid in improving the painful symptoms of fibromyalgia sufferers by reducing inflammation.
Celery seed contains a number of biologically beneficial substance, including flavonoids high in antioxidants, coumarin with anti-coagulating effects, volatile oils ,omega-6 fatty acid linoleic acid, and the powerful healing compound 3-n-butylphthlaide (3-n-B). 3-n-B is extremely effective at reducing the action of the COX-1, COX-2, and 5-LOX pain triggers. In one study of patients with long-term joint discomfort, celery seed helped reduce tenderness and improve flexibility in a remarkable 68% of patients.
Malic acid works with magnesium in the production of ATP, our body’s source for energy. In a study published in 1992 in the “Journal of Nutritional Medicine,” magnesium and malic acid are important for ATP production; the authors further postulate that fibromyalgia symptoms are mostly caused by a deficiency in magnesium and malate, also known as malic acid.
Acetyl-L-Carnitine is an amino acid and one of several forms of carnitines at work in your body. Carnitines carry certain fatty foods to mitochondria to be burned as fuels, as well as carrying away the processes’ resulting waste products. These carnitine amino acids are protein building blocks that help the body produce energy.
All carnitines are antioxidants, and this particular amino acid has been shown to improve endurance and relieve the fatigue associated with fibromyalgia and celiac disease.
This herb is considered an adaptogen, which is a class of herbs said to help build resistance to stress. In herbal medicine, rhodiola is typically used for fatigue, depression, sleep problems, poor attention span and poor memory.
In a 4 week study with 82 participants, rhodiola extracts was able to greatly reduced dysfunction and fatigue associated with stress. Significant improvements were noted in social and work function secondary to reduced fatigue and improved mood.
Coenzyme Q10 (CoQ10) A powerful Antioxidant
CoQ10 is a vitamin-like substance that is found naturally in the body. Our bodies’ natural production of CoQ10 steadily declines as our age increases, and this deficiency can be compensated with natural CoQ10 supplements.
A recent study by the University of Maryland found that CoQ10 could help reduce damage to the brain caused by stroke, improve energy levels, and increase the body’s tolerance to and recovery from exercise.
CoQ10 promotes energy production in the body in the form of ATP. Ninety-five percent of the human body’s energy is generated this way. CoQ10 helps convert food into energy and aids in metabolism.
Three different studies have found that using 100mg of CoQ10 a day produces statistically significant results, especially in combination with a daily supplement of magnesium citrate and riboflavin.
Mental Clarity Ingredients:
Bacopa is a herb long used for memory enhancement, concentration and mental alertness. Several studies indicate that bacopa may help preserve memory and enhance cognitive function.
In a 2008 study of older adults, researchers found that 12 weeks of supplementation with bacopa led to significant improvements in memory, depression, anxiety, and heart rate. In a 2001 study of healthy adults, participants showed significant improvements in memory, learning and anxiety.
SAM-e is made from amino acid methionine and ATP. Studies have shown its effective for arthritis pain and shows both analgesic and anti-inflammatory properties.
Europe has had SAM-e available by prescription for many years as an antidepressant, and it has been available over-the-counter in the US since 1996. Dr. Ascanio Polimeni, a renowned physician in Rome, Italy, stated that “… doctors in Europe prescribe SAM-e for the therapy of many conditions, including depression, chronic fatigue syndrome, and fibromyalgia.”
The U.S. Department of Health and Human Service commissioned a three-year survey of studies conducted on SAMe. The published report concluded that it is effective for depression and osteoarthritis, without the harmful side effects.
A deficiency in vitamins B12 or folic acid may reduce levels of SAMe in your body, it works best to take all three supplements together or combined.
The University of Maryland Medical Center states, “SAMe can be effective in reducing symptoms of fibromyalgia – including pain, fatigue, morning stiffness, and depressed mood.”
It is estimated that 60%-80% of Americans are deficient in magnesium. This critical mineral is responsible for over 300 enzyme reactions and is found in all of your tissues – but magnesium is mainly prominent and most important in your muscles, bones, and brain.
Magnesium can be an effective way to combat stress and studies show it improves your sleep. Your cells need magnesium to produce energy. It is necessary for many different chemical pumps to work, to stabilize membranes, and to help muscles relax.
Many people can be sensitive to variou form of Magnesium when they are supplied in high quantities. To counteract any gastrointestinal complications, we use a blend of 5 different forms of magnesium to provide maximum absorption.
Vitamin D3 is crucial for the absorption and metabolism of calcium and phosphorous, which both maintain and strengthen bones and teeth and prevent bone loss and bone disorders. It is an essential ingredient in reducing the symptoms of fibromyalgia.
D3 also protects against muscle weakness and immune system issues. It has been shown to reduce the risk of rheumatoid arthritis in women.
Greg Plotnikoff, MD, senior consultant with the Allina Center for Health Care Innovations in Minnesota published a study in 2003 on 150 people who came to a health clinic complaining of chronic pain. Virtually all of them – 93% – had extremely low vitamin D levels.
Benfotiamine (B1) | Methylcobalamin (B12) | Folic Acid
Fibrolief is loaded with the most bioavailable forms of B vitamins. Some studies have found low levels of vitamin B1 and reduced activity of some thiamine-dependent enzymes among people with fibromyalgia.
B12 deficiency is usually reported with symptoms of fatigue. Vitamin B12 is essential in converting carbs into glucose in the body. Sufficient B12 levels are linked to an increase in energy production and a decrease in fatigue and lethargy.
Folic acid is believed to play a part in mood regulation. These B vitamins also help increase the level of SAMe in your body.
We only use the most bioavailable forms of these ingredients and not the cheaper and more common cyanocobalamin (B12) and thiamine (B1).
Stabilized R-Alpha Lipoic Acid
R-ALA is a potent antioxidant that is both fat and water soluble, which improves the function of cell “transporters” that carry and distribute glucose. It is one of the few substances that can cross the blood/brain barrier and pass easily into the brain to go directly where it is needed most.
Most importantly, R-ALA is the only antioxidant that has the unique ability to self-regenerate and to also regenerate many other antioxidants, such as B vitamins.
Many studies, doctors, and researches have shown stabilized R-ALA to be up to 12 times more effective than the cheaper S-ALA found in most ALA supplements. B vitamins and R-ALA are absolutely essential ingredients in helping to reduce the symptoms of fibromyalgia and ease nerve pain.
Zinc is a mineral that has immune boosting properties and is a powerful antioxidant. Zinc is so important because it is found in every tissue in the body and is directly involved in cell division and studies have shown that low zinc is common in over half of the US population.
According to a 2010 study published by the “European Journal of Clinical Nutrition,” zinc supplementation may improve mood in women, and may even be effective for depression.
Adequate zinc levels are essential for keeping your immune system strong if you suffer from fibromyalgia.
Black Pepper Bioperine
Bioperine is an extract derived from black pepper and is found to be bioavailability enhancer of a variety of nutrients. It also has immune-suppressing, tumor-inhibiting, and antidepressant effects.
According to an article published in the Journal of Ayruveda and Integrative Medicine in 2010, piperine has been shown to increase the absorption of vitamin C, selenium, beta-carotene, vitamin A, vitamin B-6, and coenzyme Q.